Video: Farrell reacts to latest Tuilagi injury, as England forced to make change for Boks
Chris Ashton has been named as a late replacement for England's first November Test against South Africa after the injury-prone Manu Tuilagi was ruled out.
Ashton was initially omitted for Saturday's showdown at Twickenham, but the wing could yet win his first cap for four years from the bench.
Centre Tuilagi will not feature against the Springboks due to a groin injury.
The Leicester Tigers powerhouse has been beset by injury problems and will have to wait for a first Test appearance in over two years.
Ashton scored a hat-trick on his Sale Sharks debut in a European Challenge Cup win over Connacht.
The flyer returned to his homeland to put himself back in contention for an international call-up after one outstanding season with Toulon.
England co-captain Owen Farrell said that centre "seemed in high enough spirits" despite the latest setback.
"I don't think it is anything too serious, but obviously with his history, probably not one to risk."
Watch: Elliot Daly and England scrum coach Neal Hatley speak before South Africa game
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If Razor picked jaded players, where is the role of a squad? Where is the anticipated innovation from this group? The season has been a big disappointment considering the talent available (but left sitting on the sideline). Was ready for a fresh approach after the frustration of the Foster era but we only got more of the same and a timid coaching group.
Go to commentsWatching the game now I get a sense of things to come. Ref puts his flag up when Patricks legs go over the line ages after he has released the ball. That is not out in touch.
Then Tele'a has a brain fade and tries to jump into touch, slapping the ball back, when he should know and be trained in running from outside touch and jumping into the field of play with it. If he had of done that simple fix of altering his approach angle there's noway anyone is getting to him to stop the try.
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